To Napa River Inn

from San Francisco International Airport (SFO)
(via The Bay Bridge):

1. Take US-101 North toward San Francisco / Oakland.
2. In San Francisco merge onto I-80 East and cross the Bay Bridge.
3. Continue on I-80 East toward Vallejo / Sacramento, about 20 miles.
4. In Vallejo, exit onto CA-37 West (Napa / Columbus Parkway).
5. After about one mile, exit onto Highway CA-29 north toward Napa.
6. Continue on CA-29 for about 7 miles until it forks. Take the right fork, toward Downtown Napa and Lake Berryessa (CA-221).
7. As you enter Napa, the road you're on becomes Soscol Avenue. Continue on Soscol for another mile to Third Street.
8. Turn left at Third Street, crossing the bridge over the Napa River.
9. Immediately over the bridge take the first left onto Main Street. Main Street dead-ends at the Napa River Inn.

from San Francisco International Airport (SFO)
(via The Golden Gate Bridge):

1. Take US-101 North toward San Francisco for about one mile.
2. Merge onto I-380 West toward I-280.
3. Merge onto I-280 North toward San Francisco for about 6 miles.
4. In San Francisco take CA-1 toward 19th Avenue / Golden Gate Bridge.
5. Over the bridge continue on US-101 for about 18 miles to CA-37.
6. Exit onto CA-37 East toward Vallejo / Napa.
7. Continue on CA-37 for about 7 miles to CA-121.
8. Turn left onto CA-121 North towards Napa / Sonoma. Continue for about 15 miles to CA-29.
9. Turn left onto CA-29 North.
10. In Napa take the First Street exit and turn right onto First Street.
11. Immediately make another right onto California Street.
12. Go one block and turn left onto Second Street.
13. Continue on Second Street until it ends at Main Street.
14. Turn right at Main Street. Main Street dead-ends at the Napa River Inn.

from Oakland International Airport (OAK):

1. Take I-880 North toward downtown Oakland, about 6 miles.
2. In Oakland take I-980 East toward Walnut Creek.
3. After about one mile merge onto I-580 West toward San Francisco.
4. Continue on I-580 West for half a mile to I-80.
5. Merge onto I-80 East toward Vallejo / Sacramento and continue for about 20 miles.
6. In Vallejo, exit onto CA-37 West (Napa / Columbus Parkway).
7. After about one mile, exit onto Highway CA-29 North toward Napa.
8. Continue on CA-29 North for about 7 miles until it forks. Take the right fork, toward Downtown Napa and Lake Berryessa (CA-221).
9. As you enter Napa, the road you're on becomes Soscol Avenue. Continue on Soscol for another mile to Third Street.
10. Turn left at Third Street, crossing the bridge over the Napa River.
11. Immediately over the bridge take the first left onto Main Street. Main Street dead-ends at the Napa River Inn.

from Sacramento International Airport (SMF):

1. Take I-5 North toward Woodland, about 8 miles.
2. In Woodland exit onto East Main Street toward CA-113.
3. Enter CA-113 South toward Davis and continue for about 11 miles to I-80.
4. Merge onto I-80 West and go about 30 miles to CA-12.
5. Exit onto CA-12 West (Jameson Canyon Road) and take CA-12 to CA-29, about 6 miles.
6. Turn right onto CA-29 North.
7. Shortly after joining CA-29, the highway will fork. Take the right fork, toward Downtown Napa and Lake Berryessa (CA-221).
8. As you enter Napa, the road you're on becomes Soscol Avenue. Continue on Soscol for another mile to Third Street.
9. Turn left at Third Street, crossing the bridge over the Napa River.
10. Immediately over the bridge take the first left onto Main Street. Main Street dead-ends at the Napa River Inn.

from San Jose International Airport (SJC)

1. Take I-880 North toward Oakland for about 7 miles.
2. Exit at Mission Blvd toward I-680 / Sacramento.
3. Take I-680 North toward Sacramento. Continue for about 45 miles to the Benicia-Martinez bridge.
4. Immediately after crossing over the bridge, exit onto I-780 and go about 6 miles to I-80.
5. Merge onto I-80 East toward Sacramento. Go for about 3 miles to CA-37
6. Exit onto CA-37 West (Napa / Columbus Parkway).
7. After about one mile, exit onto Highway CA-29 North toward Napa.
8. Continue on CA-29 North for about 7 miles until it forks. Take the right fork, toward Downtown Napa and Lake Berryessa (CA-221).
9. As you enter Napa, the road you're on becomes Soscol Avenue. Continue on Soscol for another mile to Third Street.
10. Turn left at Third Street, crossing the bridge over the Napa River.
11. Immediately over the bridge take the first left onto Main Street. Main Street dead-ends at the Napa River Inn.